Learn more about the research projects we fund by clicking on the links below.

Alternatively, find out more about our Completed Research Projects.

Spray-on-Skin

Spray-on-Skin

Study of the Safety, Tolerability, and Efficacy of an iPS Cell-based Therapy for RDEB Delivered with a Spray-on-Skin Device ...
PASTE gene therapy in DEB

PASTE gene therapy in DEB

PASTE-Mediated Superexon Replacement of COL7A1 as a Treatment for Dystrophic Epidermolysis Bullosa ...
siRNA interference in EBS

siRNA interference in EBS

siRNA-mediated allele-specific inhibition of mutant KRT5 and KRT14 transcripts carrying frequent dominant mutations in epidermolysis bullosa simplex (EBS) ...
Dr Matthias Titeux & Prof Alain Hovnanian standing in a lab

Exon Skipping Approach to RDEB

Exon skipping approach to RDEB, with the aim to create a shorter but functional Collagen VII protein ...
Editing of RDEB fibroblasts

Editing of RDEB fibroblasts

Testing the in vivo efficacy of base and prime editing in primary fibroblasts and in a 3D skin model of ...
Rigosertib for RDEB SCC

Rigosertib for RDEB SCC

Rigosertib for recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma ...
Female scientist working in lab

Base editing of RDEB fibroblasts

Testing the efficacy of genomic base editing in dystrophic epidermolysis bullosa primary fibroblasts ...
BrB-101

BrB-101

Development of a topical gene-editing treatment to restore Collagen VII ...
Gene therapy for airway disease

Gene therapy for airway disease

Combined respiratory epithelial cell and gene therapy for amelioration of respiratory symptoms in children with Junctional Epidermolysis Bullosa ...
RDEB gene-edited skin

RDEB gene-edited skin

Pre-clinical and clinical trial for using gene-edited skin in Recessive Dystrophic Epidermolysis Bullosa ...
NanoCol

NanoCol

A nanoneedle bandage for topical intracellular COL7A1 gene therapy to accelerate wound healing in Recessive Dystrophic Epidermolysis Bullosa ...
Mission EB

Mission EB

Double blind placebo controlled study of mesenchymal intravenous stromal cell infusions in children with Recessive Dystrophic Epidermolysis Bullosa ...
FIBRX Derm

FIBRX Derm

Development of a topical gel formulation of decorin to reduce fibrosis ...
RNA Derm

RNA Derm

Development of IV-administered siRNAs targeting mutant KRT5 and KRT1 in EB Simplex ...
TXA127

TXA127

Development of an oral formulation of the peptide angiotensin-(1-7) to reduce fibrosis ...
EBGRAFT

EBGRAFT

Phase I/II ex vivo gene therapy clinical trial for RDEB using autologous skin equivalent grafts genetically corrected with a COL7A1-encoding ...
EB iPS Consortium

EB iPS Consortium

Epidermolysis Bullosa Therapeutic Reprogramming Consortium ...
Next generation genome editing

Next generation genome editing

Next generation genome editing for Recessive Dystrophic Epidermolysis Bullosa ...