Current Projects

Patients with RDEB are at an increased risk of an aggressive squamous cell carcinoma (SCC) which is usually fatal. This project ...

Study of the Safety, Tolerability, and Efficacy of an iPS Cell-based Therapy for RDEB Delivered with a Spray-on-Skin Device ...

PASTE-Mediated Superexon Replacement of COL7A1 as a Treatment for Dystrophic Epidermolysis Bullosa ...

siRNA-mediated allele-specific inhibition of mutant KRT5 and KRT14 transcripts carrying frequent dominant mutations in epidermolysis bullosa simplex (EBS) ...

Exon skipping approach to RDEB, with the aim to create a shorter but functional Collagen VII protein ...

Testing the in vivo efficacy of base and prime editing in primary fibroblasts and in a 3D skin model of ...

Rigosertib for recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma ...

Testing the efficacy of genomic base editing in dystrophic epidermolysis bullosa primary fibroblasts ...

Development of a topical gene-editing treatment to restore Collagen VII ...

Combined respiratory epithelial cell and gene therapy for amelioration of respiratory symptoms in children with Junctional Epidermolysis Bullosa ...

Pre-clinical and clinical trial for using gene-edited skin in Recessive Dystrophic Epidermolysis Bullosa ...

A nanoneedle bandage for topical intracellular COL7A1 gene therapy to accelerate wound healing in Recessive Dystrophic Epidermolysis Bullosa ...

Double blind placebo controlled study of mesenchymal intravenous stromal cell infusions in children with Recessive Dystrophic Epidermolysis Bullosa ...

Development of a topical gel formulation of decorin to reduce fibrosis ...

Development of IV-administered siRNAs targeting mutant KRT5 and KRT1 in EB Simplex ...

Development of an oral formulation of the peptide angiotensin-(1-7) to reduce fibrosis ...

Phase I/II ex vivo gene therapy clinical trial for RDEB using autologous skin equivalent grafts genetically corrected with a COL7A1-encoding ...

Epidermolysis Bullosa Therapeutic Reprogramming Consortium ...

Next generation genome editing for Recessive Dystrophic Epidermolysis Bullosa ...