Learn more about the research projects we fund by clicking on the links below.
Alternatively, find out more about our Completed Research Projects.
Current Projects
mRNA-based base editing
Evaluation of long-term effect on skin homeostasis and regeneration in a RDEB mouse model using different delivery methods of LNPs ...
Bespoke Therapy for RDEB
This study endeavours to develop personalised therapies for individuals diagnosed with RDEB ...
Therapy for JEB Airway Disease
Towards cell and gene therapy for Junctional Epidermolysis Bullosa airway disease Lay summary There has been little research into airway ...
Nova Anchora
Development of NvA-011, a recombinant version of collagen VII for topical application in Dystrophic EB ...
Base & Prime Editing for RDEB
The project aims to develop a strategy that could be used to treat a significant subset of RDEB patients carrying ...
Gene & Cell Therapy in RDEB SCC
Patients with RDEB are at an increased risk of an aggressive squamous cell carcinoma (SCC) which is usually fatal. This project ...
Spray-on-Skin
Study of the Safety, Tolerability, and Efficacy of an iPS Cell-based Therapy for RDEB Delivered with a Spray-on-Skin Device ...
PASTE gene therapy in DEB
PASTE-Mediated Superexon Replacement of COL7A1 as a Treatment for Dystrophic Epidermolysis Bullosa ...
siRNA interference in EBS
siRNA-mediated allele-specific inhibition of mutant KRT5 and KRT14 transcripts carrying frequent dominant mutations in epidermolysis bullosa simplex (EBS) ...
Exon Skipping Approach to RDEB
Exon skipping approach to RDEB, with the aim to create a shorter but functional Collagen VII protein ...
Editing of RDEB fibroblasts
Testing the in vivo efficacy of base and prime editing in primary fibroblasts and in a 3D skin model of ...
Rigosertib for RDEB SCC
Rigosertib for recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma ...
Base editing of RDEB fibroblasts
Testing the efficacy of genomic base editing in dystrophic epidermolysis bullosa primary fibroblasts ...
RDEB gene-edited skin
Pre-clinical and clinical trial for using gene-edited skin in Recessive Dystrophic Epidermolysis Bullosa ...
Mission EB
Double blind placebo controlled study of mesenchymal intravenous stromal cell infusions in children with Recessive Dystrophic Epidermolysis Bullosa ...
