InMed Pharmaceuticals has expanded its Phase II trial of INM-755, a cannabinol cream, to include adolescents. The trial is designed to enroll up to 20 patients with all four types of inherited EB - dystrophic EB, EB Simplex, Junctional EB and Kindler Syndrome - and will...
Last week, Krystal Biotech announced its submission of a Biologics License Application to the US Food and Drug Administration (FDA) seeking approval of B-VEC for the treatment of dystrophic epidermolysis bullosa (DEB). B-VEC is a non-invasive, topical gene therapy, applied to DEB wounds, providing the patient's...
Yesterday, the European Commission approved Amryt Pharma's Filsuvez®, a gel treatment for partial thickness wounds associated with dystrophic and junctional epidermolysis bullosa (EB) in patients 6 months and older. The approval was supported by data from the Phase III EASE trial, the largest ever global...
Researchers at the University of Bristol are investigating the design and development of artificial skin to benefit Epidermolysis Bullosa sufferers. Dr Naghavi Zadeh and colleagues are collaborating with Sharmila Collins, Founder and Trustee of Cure EB, to understand life with EB and care requirements. The project...
Castle Creek Biosciences raised US $112.8 million in its latest round of preferred stock financing. The financing is expected to advance Castle Creek’s cell and gene therapy pipeline, including funding the completion of a Phase III study of D-Fi, a cell-based gene therapy delivered by local...
Tetra Bio-Pharma's PPP004, a cannabinoid-derived cream, has been granted Orphan Drug Designation by the European Medicines Agency (EMA). EMA Orphan Drug Designation supports the development of investigational products that are intended to treat rare diseases affecting fewer than 5 in 10,000 people. Read the press release from...
BridgeBio Pharma and Phoenix Tissue Repair reported positive results from a phase II trial of PTR-01, an intravenously-administered recombinant collagen VII protein replacement therapy, in patients with recessive dystrophic epidermolysis bullosa (RDEB). In the trial, PTR-01 was administered once per week for four weeks and then...
Paediatric patients with recessive dystrophic epidermolysis bullosa (RDEB) are at risk of vitamin D deficiency due to large areas of skin being covered with dressings, reduced mobility, and impaired nutritional intake, according to researchers from Great Ormond Street. In new research, they recommend vitamin D supplementation...
The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended approval of Amryt Pharma’s Filsuvez, a gel treatment for partial thickness wounds associated with dystrophic and junctional epidermolysis bullosa in patients 6 months and older. The European Commission and the UK’s Medicines...